The day will honor Indian heritage, highlighting the bond between the US and the Indian American community.
Continuing tradition, President Biden will light a Diya lamp in the Blue Room before his remarks.
He will host a reception for Indian Americans, marking his final Diwali celebration at the White House.
A special message from astronaut Sunita Williams will be introduced during the event.
Williams, a practicing Hindu, has previously celebrated Diwali from the International Space Station.
Nootana, a classical South Asian ensemble, will provide musical entertainment alongside the Marine Corps Band.
Last year, President Biden shared a heartfelt message about Diwali's themes of wisdom, love, and unity.
On Twitter, President Joe Biden shared, Today, Jill and I lit the Diya to symbolize Diwali's message of seeking light over darkness. May we embrace the spirit of this holiday and reflect on our shared strength.